All of this discussion makes me realise how much I love compression. As a bass player and former audio tech, it really can be the difference between a great mix and a mediocre one. Especially live…
Guitarists need to have enough dynamic range in their sound to give them options, bassists too… But I’d be worrying about the hell you’re giving your sound guy if your range is too big (especially if your sound changes are done with the volume knob which isn’t particularly predicts le) to try and keep the mix well balanced.
Personally, as a bassist, compression is the first thing in my rig, doesn’t touch soft notes but reins in hard notes (not the way they sound so much as their actual dB level) and that gives my sound guy a good solid sound to work with that sits pretty consistently in the mix across differently styles.
I would set your gains so that they hit that sweet spot on your amp, even if that means dropping or boosting mod output… But I’d also be trying to address dynamic shifts through presets or pedals instead of modulating guitar output with your volume knob.